The venom of the giant Tiger Widow spider is one of the most toxic substances in existence. A single drop of this substance is capable of causing death within minutes. It is also one of the only effective weapons against a Djinn, as it drains the magical being of energy and endurance. This has the effect of slowing down the normally super-fast Djinn, making it possible for other attacks to be launched successfully. Captain Soto used Tiger Widow venom to defeat Nadakhan and imprison him in the Teapot of Tyrahn. Jay harvested some of this venom on Tiger Widow Island for use on Nadakhan.